became a real sensation in the cosmetology world. Polynucleotides are the “bricks” repairing the skin from the inside, increasing the collagen production, and being a powerful growth factor stimulator.
PDRN is a “pro-medicine” providing the cells with a sufficient quantity of desoxyribonucleotides, desoxyribonucleosides and nitrogenous bases.
Safety and efficiency
The proliferative activity exerted by PDRN was significantly counteracted by the A2 antagonist 3, 7-Dimethyl-lpropargylxanthine (DMPX), but not by the A, antagonist 8-cyclopentyl-1, 3- dipropylxanthine (PD 116,948, DPCPX). Accordingly, the trophic action of PDRN was mimicked by the A2 agonist N6-[2-(3,5-Dimethoxyphenyl)-2-(methylphenyl)-ethyl adenosine (DPMA), while the A, agonist N6-Cyclopenthyladenosine (CPA) did not show any effect. In microfluorimetric studies, we observed that PDRN and adenosine increased the concentration of cytosolic calcium ions. The PDRNevok. ed calcium rise was dose- dependent and DMPX sensitive. Taken together, our results suggest that PDRN may operate as a pro-drug providing the cultured cells with an effective amount of mitogenic deoxyribonucleotides, deoxyribonucleosides and bases; moreover, cell proliferation enhancement that has been induced by PDRN seems to be mediated, at least in part, by the activation of purinergic receptors of the A2 subtype.
By its structure PDRN is a fragment of DNA molecule, a unique polymeric molecule with various positive features influencing the cellular processes in the human body and homeostasis without any toxicity and contraindications.The scientific researches showed that low-molecular DNA with a molecular weight below 500 kDa bears no genetic information. It’s known that such a low-molecular DNA cannot induce a genetic transformation even in bacterial systems. There was no allergic or other adverse reactions and severe side effects.